Fig. 1. Frequencies of CD4⁺CD25^hiCD127^low/- Treg in peripheral blood of RA patients and healthy controls. (a) CD25⁺CD127^low/- Treg cells were gated within the CD4⁺ T cell population in peripheral blood mononuclear cells (PBMCs) from RA patients. Almost all CD4⁺CD25^hiCD127^low/^- cells are Foxp3⁺ cells. (b) Frequencies of CD4⁺CD25^hiCD127^low/- Tregs were compared between healthy controls (3.17±1.49%) and RA patients (3.77±1.98%) (p>0.05). (c) Frequencies of Tregs were compared between healthy controls and RA patients with different levels of disease activity (p>0.05). The p value was measured with Mann-Whitney test. n.s., not significant.